Since the size of red blood cells is comparable to those of micro-vessels and capillaries, in microcirculation blood cannot be treated as continuum uid. In physiological conditions, red blood cells undergo tremendous deformation due to the combined e ect of uid forcing and constraints from various boundaries. We have conducted a multi- disciplinary study and created a high- delity multiscale model to relate cell deformations to the internal stress distribution inside the cell down to the molecular level. This model can be used to predict the structural stability and structural damage which leads to pathological conditions. Of particular interest is the in vivo mechanical performance of cells with mutations, diseases (e.g. malaria), or after storage (as happens in blood transfusion).
Professor Qiang Zhu